Derek S. Welsbie

Cell-Intrinsic Vulnerability and Immune Activation Cooperate to Drive Degeneration in a Mitochondrial Complex I Deficiency Model of Optic Neuropathy

This study investigates how mitochondrial dysfunction and immune activation contribute to retinal ganglion cell degeneration in optic neuropathy using transgenic models.

Identification a Compact Promoter using a New Promoter Selection Strategy and Engineering Hybrid Pol II/III Enable Efficient Genome Editing in Human Retinal Ganglion Cells

The paper identifies a compact Pol II promoter and hybrid Pol II/III promoters to enable efficient single-AAV delivery of SpCas9 for genome editing in human retinal ganglion cells.

Afadin Sorts Different Retinal Neuron Types into Accurate Cellular Layers

This study shows that Afadin is essential for sorting retinal neuron types into correct cellular layers, but not for their survival or synaptic partner selection.

Recovery of retinal terminal fields after traumatic brain injury: evidence of collateral sprouting and sexual dimorphism

This study shows that retinal ganglion cell axons can re-establish terminal fields after traumatic brain injury through collateral sprouting, with sex differences in recovery.

Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration

This study identifies OPTN's role in axonal mitochondria transport and shows its loss contributes to neurodegeneration in models of ALS and NTG.

Thyroid hormone signaling specifies cone subtypes in human retinal organoids

The paper shows thyroid hormone signaling controls the temporal switch between S and L/M cone fates in human retinal organoids.