Author

Brian Chirn

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Aditya BardiaiD· 1 shared Annamária SzabolcsiD· 1 shared Ben S. WittneriD· 1 shared Daniel A. HaberiD· 1 shared Dante Che· 1 shared David Tsai TingiD· 1 shared Devon F. WileyiD· 1 shared Douglas B. FoxiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Aditya BardiaORCID

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1 paper

Recent·Most cited

CDKN1B (p27kip1) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors.

E. Philip Horwitz, Taronish D. Dubash, Annamária Szabolcs, Ben S. Wittner, Johannes Kreuzer, Robert Tyler Morris, Aditya Bardia, Brian Chirn, Devon F. Wiley, Dante Che, Hunter C. Russell, Xcanda Ixchel Herrera Lopez, Douglas B. Fox, Ezgi Antmen, Risa Burr, , Daniel A. Haber

This study identifies CDKN1B as a regulator of drug-tolerant persister CTCs by preventing polyploidy after mitotic inhibitor treatment in breast cancer.

Proceedings of the National Academy of Sciences · Jul 7, 2025Peer-reviewedCancer Biology