CDKN1B (p27kip1) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors.
E. Philip Horwitz, Taronish D. Dubash, Annamária Szabolcs, Ben S. Wittner, Johannes Kreuzer, Robert Tyler Morris, Aditya Bardia, Brian Chirn, Devon F. Wiley, Dante Che, Hunter C. Russell, Xcanda Ixchel Herrera Lopez, Douglas B. Fox, Ezgi Antmen, Risa Burr, , Daniel A. Haber
This study identifies CDKN1B as a regulator of drug-tolerant persister CTCs by preventing polyploidy after mitotic inhibitor treatment in breast cancer.
Proceedings of the National Academy of Sciences · Jul 7, 2025Peer-reviewedCancer Biology