The E3 ligase HECTD4 regulates COX-2 dependent tumor progression and metastasis
Joanna A. Vuille, Cem Tanrıöver, Ezgi Antmen…·Daniel A. Haber
The paper identifies HECTD4 as a tumor and metastasis suppressor that targets COX-2 for degradation, with COX-2 stabilization driving pro-tumorigenic effects in breast cancer.