Selective Activation of NaV1.3 Restores Lymphatic Contractility in Age and Injury
Katarina J. Ruscic, Reetu Singh, Lingshan Liu, Marla Marquez, Johanna J. Rajotte, Pinji Lei, Olivia D. Miller, Brian J. Kinsman, Meghan J. O’Melia, Dhruv Singhal, James W. Baish, Leigh D. Plant, Timothy P. Padera
This study identifies NaV1.3 as a druggable target in adult lymphatic muscle that can restore contractility in aging and radiation injury.
bioRxiv · Dec 17, 2025 · PreprintPhysiology