Timothy P. Padera

Lymph node contraction links sex-biased naive CD8 T cell decline to compromised antigen recognition during middle age

This study identifies sex-biased mechanisms of immune aging in males, showing lymph node contraction reduces naive CD8 T cell availability and compromises cancer antigen recognition, with potential therapeutic interventions.

Selective Activation of NaV1.3 Restores Lymphatic Contractility in Age and Injury

This study identifies NaV1.3 as a druggable target in adult lymphatic muscle that can restore contractility in aging and radiation injury.

Overcoming impaired antigen presentation in tumor draining lymph nodes facilitates immunotherapy

This study shows that breast tumors impair antigen presentation in local lymph nodes, which can be overcome by delivering IL1β or adjuvants to distant lymph nodes, improving anti-cancer immune responses.

Optimizing Cancer Vaccinations Using a Physiologically Based Pharmacokinetic (PBPK) Model

This paper develops a PBPK model to optimize cancer vaccine design by simulating antigen transport and immune responses across organs.

The anti-virus T cell response dominates the anti-cancer response in oncolytic virus therapy

This study shows oncolytic virus therapy primarily elicits anti-virus T cell responses rather than anti-cancer responses, explaining limited clinical efficacy in metastatic disease.

Single-nuclear transcriptomics of lymphedema-associated adipose reveals a pro-lymphangiogenic stromal cell population

The paper uses single-nuclear RNA sequencing to analyze adipose tissue in lymphedema patients, identifying a stromal cell population that promotes lymphangiogenesis.

A Multiresolution Approach with Method-Informed Statistical Analysis for Quantifying Lymphatic Pumping Dynamics

This paper develops a multiresolution imaging and analysis approach to quantify lymphatic pumping dynamics, improving measurement reliability across species and conditions.