In vitro ribosome synthesis and evolution through ribosome display
Michael J. Hammerling, Brian R. Fritz, Danielle J. Yoesep, Do Soon Kim, Erik D. Carlson, Michael C. Jewett
This study develops an in vitro method for ribosome synthesis and evolution called RISE, demonstrating its ability to select for ribosome variants resistant to clindamycin and revealing positive epistasis in successful genotypes.
Nature Communications · Feb 28, 2020Peer-reviewedSynthetic Biology