Author

Brian S. MacTavish

The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Di ZhuiD· 2 shared Douglas J. KojetiniD· 2 shared Jinsai ShangiD· 2 shared Theodore M. KameneckaiD· 2 shared Liudmyla Arifova· 1 shared Mei LiiD· 1 shared Mithun Nag Karadi GiridhariD· 1 shared Qianzhen ShaoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Di ZhuORCID

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2 papers

Recent·Most cited

Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy

Liudmyla Arifova, Brian S. MacTavish, Zane T. Laughlin, Mithun Nag Karadi Giridhar, Jinsai Shang, Mei Li, Xiaoyu Yu, Di Zhu, Theodore M. Kamenecka, Douglas J. Kojetin

The paper investigates how covalent inhibitors of PPARγ shift its conformational state, affecting ligand binding and inhibitor efficacy.

eLife · Jan 21, 2026Peer-reviewedBiochemistry

Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states

Brian S. MacTavish, Di Zhu, Jinsai Shang, Qianzhen Shao, Yuanjun He, Zhongyue John Yang, Theodore M. Kamenecka, Douglas J. Kojetin

This study identifies a PPARγ ligand series that shifts the receptor's conformational ensemble between active and repressive states, revealing how subtle chemical changes influence its function.

Nature Communications · Feb 28, 2025Peer-reviewedBiophysics