Xiaoyu Yu

The paper investigates how covalent inhibitors of PPARγ shift its conformational state, affecting ligand binding and inhibitor efficacy.

This study determines the structural properties of full-length IMP2, revealing its dimeric conformation and RNA-induced changes, which may inform drug design.

This study compares FX-909 to other covalent PPARγ inverse agonists, showing improved corepressor-selective inverse agonism and stabilization of a repressive conformation.

This paper investigates the activation mechanism of NR4A-RXR heterodimers using a diverse RXR ligand set, revealing both classical and non-classical activation pathways.