Zane T. Laughlin

The paper investigates how covalent inhibitors of PPARγ shift its conformational state, affecting ligand binding and inhibitor efficacy.

This study compares FX-909 to other covalent PPARγ inverse agonists, showing improved corepressor-selective inverse agonism and stabilization of a repressive conformation.

The paper describes the engineering of synthetic multivalent VHH antibodies against SARS-CoV-2 spike protein and shows how mutations affect their binding.