Author

Yuanjun He

The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & TechnologyORCID 0000-0002-3983-5529Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Theodore M. KameneckaiD· 3 shared Douglas J. KojetiniD· 2 shared Abdalla D. MohamediD· 1 shared Allancer NunesiD· 1 shared Borui ZhangiD· 1 shared Brian Hughes· 1 shared Brian S. MacTavish· 1 shared Carolina Soto-PalmaiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

Theodore M. KameneckaORCID

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3 papers

Recent·Most cited

Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers

Xiaoyu Yu, Yuanjun He, Theodore M. Kamenecka, Douglas J. Kojetin

This paper investigates the activation mechanism of NR4A-RXR heterodimers using a diverse RXR ligand set, revealing both classical and non-classical activation pathways.

bioRxiv · Mar 19, 2025Biochemistry

Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states

Brian S. MacTavish, Di Zhu, Jinsai Shang, Qianzhen Shao, Yuanjun He, Zhongyue John Yang, Theodore M. Kamenecka, Douglas J. Kojetin

This study identifies a PPARγ ligand series that shifts the receptor's conformational ensemble between active and repressive states, revealing how subtle chemical changes influence its function.

Nature Communications · Feb 28, 2025Peer-reviewedBiophysics

Development of novel flavonoid senolytics through phenotypic drug screening and drug design

Lei Justan Zhang, Rahagir Salekeen, Carolina Soto-Palma, Yuanjun He, Osama Elsallabi, Brian Hughes, Allancer Nunes, Wentao Xu, Borui Zhang, Abdalla D. Mohamed, Sara J. McGowan, Luise A. Angelini, Ryan D. O'Kelly, Theodore M. Kamenecka, Laura J. Niedernhofer, Paul D. Robbins

This study develops two novel flavonoid senolytics through phenotypic drug screening and design, showing enhanced senolytic activity and healthspan extension in a mouse model.

bioRxiv · Oct 27, 2024 · PreprintCell Biology