Desmoplakin Haploinsufficiency Underlies Cell-Cell Adhesion Failure in DSP Cardiomyopathy and is Rescued by Transcriptional Activation
Eric D. Smith, Karen Jin, Brianna Ferguson, Yao-Chang Tsan, Samuel J. DePalma, Joshua K. Meisner, Aaron Renberg, Kenneth C Bedi, Sabrina Friedline, Kenneth B. Margulies, Brendon M. Baker, Adam S. Helms
This study shows that DSP haploinsufficiency causes cell-cell adhesion failure in cardiomyopathy and that increasing DSP expression rescues this defect.
bioRxiv · Jun 1, 2025 · PreprintGenetics