Yao-Chang Tsan

The paper maps and redesigns the MYBPC3 promoter to enhance expression and treat haploinsufficient hypertrophic cardiomyopathy.

This paper introduces a framework to model haploinsufficiency-mediated human disorders by modulating gene dosage through splicing, demonstrating its application in creating accurate animal models for cardiomyopathies.

The paper uses donor-matched iPSC-derived FAPs to show that T2D GWAS signals are enriched in adipogenic FAP subtypes under high-insulin exposure.

This study shows that DSP haploinsufficiency causes cell-cell adhesion failure in cardiomyopathy and that increasing DSP expression rescues this defect.

This study investigates the role of ASXL3 in cardiac development using mouse and human models, finding that its loss leads to cardiac abnormalities and extracellular matrix dysfunction.

This study shows ASXL3 regulates cortical neuron fate through extrinsic signaling and epigenetic pathways, linking it to ASD risk.