Author

Sabrina Friedline

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Aaron RenbergiD· 3 shared Adam S. HelmsiD· 3 shared Joshua K. MeisneriD· 3 shared Yao-Chang TsaniD· 3 shared Elizabeth D. Hughes· 2 shared Eric D. SmithiD· 2 shared Jacob Otto KitzmaniD· 2 shared Jennasea LicataiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Aaron RenbergORCID

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Author profile →

3 papers

Recent·Most cited

Mapping and rewiring the MYBPC3 promoter for rescue of haploinsufficiency driven hypertrophic cardiomyopathy

Aaron Renberg, Savannah Coppersmith, Owen L. Merritt, Yao-Chang Tsan, Esraa Ismail, Jennasea Licata, Maya U. Sheth, Revant Gupta, Anshul Bharat Kundaje, Sabrina Friedline, Hayden C. Helms, Elizabeth D. Hughes, Zachary Thomas Freeman, George Powell, James S. Ware, , Adam S. Helms

The paper maps and redesigns the MYBPC3 promoter to enhance expression and treat haploinsufficient hypertrophic cardiomyopathy.

bioRxiv · Sep 22, 2026 · PreprintMolecular Biology

Genomic Engineering of Gene Dosage: A Generalizable Framework for Modeling Haploinsufficiency-Mediated Human Disorders through Splicing Modulation

Eric D. Smith, Joshua K. Meisner, Abbey Bullard, Connor Ward, Jennasea Licata, Cathy Smith, Colleen M. Kelly, Zachary T LaRochelle, Sabrina Friedline, Aaron Renberg, Riley Yucius, Jesse Lange, Elizabeth D. Hughes, Thomas L. Saunders, Zachary Thomas Freeman, , Adam S. Helms

This paper introduces a framework to model haploinsufficiency-mediated human disorders by modulating gene dosage through splicing, demonstrating its application in creating accurate animal models for cardiomyopathies.

bioRxiv · Sep 22, 2026 · PreprintGenetics

Desmoplakin Haploinsufficiency Underlies Cell-Cell Adhesion Failure in DSP Cardiomyopathy and is Rescued by Transcriptional Activation

Eric D. Smith, Karen Jin, Brianna Ferguson, Yao-Chang Tsan, Samuel J. DePalma, Joshua K. Meisner, Aaron Renberg, Kenneth C Bedi, Sabrina Friedline, Kenneth B. Margulies, Brendon M. Baker, Adam S. Helms

This study shows that DSP haploinsufficiency causes cell-cell adhesion failure in cardiomyopathy and that increasing DSP expression rescues this defect.

bioRxiv · Jun 1, 2025 · PreprintGenetics