Oct4 mediated inhibition of Lsd1 activity promotes the active and primed state of pluripotency enhancers
Lama AlAbdi, Debapriya Saha, Ming He, Mohd Saleem Dar, Sagar M. Utturkar, Putu Ayu Sudyanti, Stephen McCune, Brice H. Spears, James A. Breedlove, Nadia A. Lanman, Humaira Gowher
The paper shows Oct4 inhibits Lsd1 activity, maintaining H3K4me1 at pluripotency enhancers and promoting a primed state that can be reactivated.
Cell Reports · Feb 1, 2020Peer-reviewedDevelopmental Biology