Sagar M. Utturkar

Extravascular coagulation stabilizes pro-fibrotic stromal states via tumor-intrinsic PAR1 signaling in pancreatic ductal adenocarcinoma

This study identifies extravascular coagulation as a regulator of fibrotic stromal states in PDAC via tumor-intrinsic PAR1 signaling, showing PAR1 inhibition can reprogram the tumor-promoting stroma.

VEZF1 facilitates pluripotency exit by regulating developmental transcriptional programs and CTCF occupancy

PBRM1-Dependent PBAF Targeting is Required for EMT and Metastasis in Breast Cancer

This study shows that PBRM1 in PBAF is essential for EMT and metastasis in breast cancer by enabling promoter targeting and DNA accessibility for TGFβ1-inducible genes.

KMT5C-H4K20me3 drives changes in epigenetic landscape independent of H3K9me3

This paper shows KMT5C-H4K20me3 affects the epigenetic landscape independently of H3K9me3, promoting activating marks and protecting genome regions from uncontrolled expression.

Fusobacterium nucleatum produces previously unappreciated AHR-activating metabolites and promotes CRC cell proliferation via the AHR-TERT axis

This study identifies Fusobacterium nucleatum-produced indole metabolites that activate the AHR-TERT axis, promoting CRC cell proliferation and revealing FTIN as a potential biomarker.

Activation of PP2A-B56α leads to aberrant EGFR signaling and proliferative phenotypes in PDAC

This study shows that activating PP2A-B56 in PDAC increases EGFR signaling and promotes tumor growth, suggesting a new therapeutic target.

Canonical microRNA loss drives tumor development implicating therapeutic efficacy of enoxacin in angiosarcoma

The paper shows that loss of miRNA processing drives angiosarcoma and that enoxacin enhances miRNA expression, reducing tumor cell viability and migration.

Loss of Bicra/Gltscr1 leads to a defect in fetal liver macrophages responsible for erythrocyte maturation in mice.

This study shows that Bicra/Gltscr1 knockout mice die perinatally due to defective fetal liver macrophages that impair erythrocyte maturation.

Oct4 mediated inhibition of Lsd1 activity promotes the active and primed state of pluripotency enhancers

The paper shows Oct4 inhibits Lsd1 activity, maintaining H3K4me1 at pluripotency enhancers and promoting a primed state that can be reactivated.