Mohd Saleem Dar

This study develops SMYD3 proteolysis targeting chimeras (PROTACs) for HPV-negative head and neck squamous cell carcinoma, showing effective SMYD3 degradation and reduced oncogenic activity.

This study identifies SUV420H1 as a driver in HPV-negative HNSCC, showing its role in proliferation, invasion, and immune evasion, and suggests targeting it to improve immunotherapy response.

The paper shows that Dnmt3bas coordinates transcriptional induction and alternative splicing of Dnmt3b to produce catalytically active Dnmt3b1.

The paper shows Oct4 inhibits Lsd1 activity, maintaining H3K4me1 at pluripotency enhancers and promoting a primed state that can be reactivated.