Nadia A. Lanman

This study identifies extravascular coagulation as a regulator of fibrotic stromal states in PDAC via tumor-intrinsic PAR1 signaling, showing PAR1 inhibition can reprogram the tumor-promoting stroma.

This study shows that SCN2A deficiency in human brain assembloids disrupts cortico-striatal circuitry by impairing axonal projections and synaptic transmission, leading to hyperexcitability.

Pert2Mol generates molecular structures from paired transcriptomic and morphological data using a multi-modal framework, achieving better performance than single-modality or diffusion-based methods.

This study uses snRNA-seq to analyze gene expression changes in Scn2a-deficient mice, identifying disrupted pathways in neuronal subtypes of the prefrontal cortex.

This study investigates the effects of the SCN2A-L1342P mutation in human cortical organoids, finding increased neuronal excitability, enhanced synaptic transmission, and transcriptomic changes related to synaptic and developmental pathways.

This study shows that diet-induced obesity worsens pre-cancerous changes in mice infected with Helicobacter pylori, particularly in those with genetic predispositions to gastric disease.

This paper develops a mouse model of chronic prostatic inflammation that mirrors human BPH by showing similar immune and fibroblast features identified through scRNA-seq.

PertFlow jointly predicts gene expression and cellular morphology from drug perturbations, achieving high correlation and expert-rated image similarity.

AnnotateAnyCell reduces annotation time for histopathological images by 25% using a semi-supervised framework with active contrastive learning and human-in-the-loop feedback.

This study shows that activating PP2A-B56 in PDAC increases EGFR signaling and promotes tumor growth, suggesting a new therapeutic target.

The paper shows that loss of miRNA processing drives angiosarcoma and that enoxacin enhances miRNA expression, reducing tumor cell viability and migration.

The paper links an age-associated CD8+ T cell subset to symptomatic benign prostatic hyperplasia through immune aging mechanisms.

This paper shows that gene therapies can reduce absence seizures in DBA/2J mice with Scn2a deficiency by restoring NaV1.2 or introducing human KV1.1.

This study shows that restoring NaV1.2 expression in adulthood rescues social deficits and improves neuronal signal-to-noise ratio in Scn2a-deficient mice.

The paper identifies lipid-rich macrophage subpopulations in BPH that correlate with prostate size and urinary symptoms.

This study identifies CXCL17 upregulation and macrophage subsets in mouse prostate under steroid hormone imbalance, linking them to foam cell formation and inflammation.

This study shows that Set1-mediated histone H3K4 methylation is essential for azole-induced expression of ergosterol biosynthesis genes and antifungal drug resistance in C. glabrata.

This study shows that R-loop accumulation in aging Drosophila photoreceptor neurons correlates with gene expression loss and visual function decline, and that Top3β and RNase H1 can mitigate these effects.

This study shows that severe NaV1.2 deficiency increases neuronal excitability in adult mice, challenging the current understanding of its role in autism and epilepsy.

The paper shows Oct4 inhibits Lsd1 activity, maintaining H3K4me1 at pluripotency enhancers and promoting a primed state that can be reactivated.