Author

Brigitte Allard

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Jennifer KirchherriD· 2 shared Nancie M. ArchiniD· 2 shared Alana L. KelleriD· 1 shared Anne‐Marie W. TurneriD· 1 shared Anthony D. Fenton· 1 shared Carley N GrayiD· 1 shared David M. MargolisiD· 1 shared Derek H. JanssensiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

Jennifer KirchherrORCID

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Author profile →

2 papers

Recent·Most cited

Integrator complex subunit 12 knockout overcomes a transcriptional block to HIV latency reversal

Carley N Gray, Manickam Ashokkumar, Derek H. Janssens, Jennifer Kirchherr, Brigitte Allard, Emily Hsieh, Terry L Hafer, Nancie M. Archin, Edward P. Browne, Michael Emerman

This study identifies INTS12 knockout as a method to enhance HIV latency reversal by overcoming a transcriptional block, improving reactivation in CD4 T cells from HIV-positive individuals.

eLife · Apr 10, 2025Peer-reviewedMicrobiology

BET Degraders Reveal BRD4 Disruption of 7SK and P-TEFb is Critical for Effective Reactivation of Latent HIV in CD4+ T-cells

Anne‐Marie W. Turner, Frances M. Bashore, Shane D. Falcinelli, Joshua A. Fox, Alana L. Keller, Anthony D. Fenton, Renee F. Geyer, Brigitte Allard, Jennifer Kirchherr, Nancie M. Archin, Lindsey Ingerman James, David M. Margolis

This study shows that BRD4 degraders are less effective than BET inhibitors in reactivating latent HIV in CD4+ T-cells, highlighting the importance of BRD4's role in disrupting 7SK and P-TEFb.

Journal of Virology · Mar 11, 2025Peer-reviewedMolecular Biology