A CAR-T Cell-Based Strategy for Eliminating Pathogenic Microglia in ALS
M.E. Cicardi, Daniela Tejada-Martínez, Shashirekha S. Markandaiah, Karthik Krishnamurthy, Chiara Scopa, Brij Oza, Ivette Martorell Serra, Andrea Feci, Edoardo Manca, Adam Eugene Snook, Aaron R. Haeusler, Piera Pasinelli, Davide Trotti
CAR-T cells targeting uPAR selectively ablate pathogenic microglia while sparing neurons, enabling precision immunotherapy for ALS.
bioRxiv · Dec 29, 2025 · PreprintNeuroscience