Author

Chiara Scopa

Thomas Jefferson UniversityORCID 0000-0003-4965-5334Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

Davide TrottiiD· 3 shared M.E. CicardiiD· 3 shared Marco TrizzinoiD· 3 shared Gijs W.E. SanteniD· 2 shared Harald M. M. MikkersiD· 2 shared Samantha A. BrugmanniD· 2 shared Samantha M. BarnadaiD· 2 shared Aaron R. HaeusleriD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersNeuroscience

Davide TrottiORCID

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Author profile →

4 papers

Recent·Most cited

NeurosciencebioRxivPreprintDec 29, 2025

A CAR-T Cell-Based Strategy for Eliminating Pathogenic Microglia in ALS

M.E. Cicardi, Daniela Tejada-Martínez, Shashirekha S. Markandaiah…·Davide Trotti

CAR-T cells targeting uPAR selectively ablate pathogenic microglia while sparing neurons, enabling precision immunotherapy for ALS.

DOI 10.64898/2025.12.29.696307

humanproteomics

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Developmental BiologybioRxivPreprintApr 3, 2024

ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial to mesenchymal transition in cranial neural crest lineage commitment

Samantha M. Barnada, Aida Giner de Gracia, Cruz Morenilla‐Palao…·Marco Trizzino

The paper shows ARID1A-haploinsufficiency impairs EMT in CNCC specification by disrupting ARID1A-BAF binding at EMT enhancers, which affects ZIC2 occupancy and leads to aberrant neuronal gene activation.

2 citations

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GenomicsbioRxivPreprintNov 24, 2022

JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer disease

Chiara Scopa, Samantha M. Barnada, M.E. Cicardi…·Marco Trizzino

This study identifies JUN upregulation as a driver of transposable element mobilization, innate immune activation, and impaired neurogenesis in Alzheimer's disease.

DOI 10.1101/2022.11.24.517794

humanexperimental assay

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GenomicsNature CommunicationsPeer-reviewedNov 9, 2021

Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders

Luca Pagliaroli, Patrizia Porazzi, Alyxandra T. Curtis…·Marco Trizzino

This study shows that failure to switch from ARID1A-BAF to ARID1B-BAF in patient-derived cells impairs neural crest formation in Coffin-Siris syndrome.

41 citations

humanbulk RNA-seq

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