Novel inhibitors of acute, axonal DLK palmitoylation are neuroprotective and avoid the deleterious side effects of cell-wide DLK inhibition
Xiaotian Zhang, Hey‐Kyeong Jeong, Jingwen Niu, Sabrina M. Holland, Brittany N. Rotanz, John Gordon, Margret B. Einarson, Wayne E. Childers, Gareth M. Thomas
The paper identifies novel compounds that inhibit DLK palmitoylation in axons, providing neuroprotection without causing cytoskeletal disruption seen with broader DLK inhibition.
bioRxiv · Apr 19, 2024 · PreprintNeuroscience