Sabrina M. Holland

The paper identifies novel compounds that inhibit DLK palmitoylation in axons, providing neuroprotection without causing cytoskeletal disruption seen with broader DLK inhibition.

This study identifies mechanisms explaining why DLK couples to JNK3 rather than other MAPKs, showing JNK3 palmitoylation facilitates pro-degenerative axon-to-soma signaling.

This study shows that ZDHHC17 couples DLK and NMNAT2 pathways to control both somal and distal axon degeneration after optic nerve crush.

This study identifies novel inhibitors of DLK palmitoylation using high-content screening, finding ketoconazole reduces DLK palmitoylation and c-Jun phosphorylation in neuronal models.