Author

Jingwen Niu

Temple UniversityORCID 0000-0001-5456-1485Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Gareth M. ThomasiD· 5 shared Sabrina M. HollandiD· 3 shared Hey‐Kyeong Jeong· 2 shared Kaitlin M. ColluraiD· 2 shared Luiselys M. Hernandez· 2 shared Andrea KetschekiD· 1 shared Audrey Montersino· 1 shared Brittany N. Rotanz· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersNeuroscience

Gareth M. ThomasORCID

Mutual co-authors in cluster

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5 papers

Recent·Most cited

NeurosciencebioRxivPreprintApr 19, 2024

Novel inhibitors of acute, axonal DLK palmitoylation are neuroprotective and avoid the deleterious side effects of cell-wide DLK inhibition

Xiaotian Zhang, Hey‐Kyeong Jeong, Jingwen Niu…·Gareth M. Thomas

The paper identifies novel compounds that inhibit DLK palmitoylation in axons, providing neuroprotection without causing cytoskeletal disruption seen with broader DLK inhibition.

6 citations

humanexperimental assay

𝕏 PostBluesky

NeuroscienceNature CommunicationsPeer-reviewedJun 22, 2021

The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation

Feng Li, Tsz Y. Lo, Leann Miles…·Yuanquan Song

This study identifies the Piezo-Atr-Chek1-Cdc25 pathway as an inhibitory mechanism for axon regeneration, showing that disrupting it enhances regeneration in Drosophila and mammals.

55 citations

Drosophilamouse

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NeurosciencebioRxivPreprintNov 17, 2020

Palmitoylation Couples DLK to JNK3 to Facilitate Pro-degenerative Axon-to-Soma Signaling

Jingwen Niu, Sabrina M. Holland, Andrea Ketschek…·Gareth M. Thomas

This study identifies mechanisms explaining why DLK couples to JNK3 rather than other MAPKs, showing JNK3 palmitoylation facilitates pro-degenerative axon-to-soma signaling.

1 citation

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 16, 2020

JAK1 palmitoylation by ZDHHC3/7 is Essential for Neuropoietic Cytokine Signaling and DRG Neuron Survival

Luiselys M. Hernandez, Audrey Montersino, Jingwen Niu…·Gareth M. Thomas

1 citation

mouseexperimental assay

𝕏 PostBluesky

NeuroscienceCell ReportsPeer-reviewedNov 1, 2020

Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17

Jingwen Niu, Shaun S. Sanders, Hey‐Kyeong Jeong…·Gareth M. Thomas

This study shows that ZDHHC17 couples DLK and NMNAT2 pathways to control both somal and distal axon degeneration after optic nerve crush.

43 citations

mouseexperimental assay

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