Gareth M. Thomas

The paper identifies S-acylation of GAPDH on cysteine 247 by ZDHHC5 and ZDHHC17 as essential for its association with axonal transport vesicles.

The paper identifies ATF2 phosphorylation as a key driver of neuron apoptosis and shows that inhibiting ATF2 protects neurons in culture and in vivo.

DACIT enables in vitro study of axon-cancer cell interactions in 2D and 3D by separating neuronal soma from axons and cancer cells into distinct compartments.

This study identifies ZDHHC9 as a key regulator of oligodendrocyte morphology and myelination, showing its role in palmitoylation of MBP and its impact on XLID.

The paper identifies novel compounds that inhibit DLK palmitoylation in axons, providing neuroprotection without causing cytoskeletal disruption seen with broader DLK inhibition.

This study shows that palmitoylation of AnkG-190 stabilizes its localization in dendritic spines, and lithium reduces this modification, affecting its function and interaction with PSD-95.

This study identifies the Piezo-Atr-Chek1-Cdc25 pathway as an inhibitory mechanism for axon regeneration, showing that disrupting it enhances regeneration in Drosophila and mammals.

This study identifies mechanisms explaining why DLK couples to JNK3 rather than other MAPKs, showing JNK3 palmitoylation facilitates pro-degenerative axon-to-soma signaling.

This study identifies ZDHHC14 as a neuronal palmitoyl acyltransferase that regulates PSD93 and Kv1 channel clustering at the axon initial segment, affecting neuronal excitability.

This study shows that ZDHHC17 couples DLK and NMNAT2 pathways to control both somal and distal axon degeneration after optic nerve crush.

This study identifies novel inhibitors of DLK palmitoylation using high-content screening, finding ketoconazole reduces DLK palmitoylation and c-Jun phosphorylation in neuronal models.