Author

Bryan A. Leland

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:software / tool· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Amy ZhaoiD· 1 shared Andrea L. Halweg‐EdwardsiD· 1 shared Andrew D. GarstiD· 1 shared Angela C. Chen· 1 shared Chad D. Sanada· 1 shared Charlie Johnson· 1 shared Christopher G. Abraham· 1 shared Clint Davis· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetics

Amy ZhaoORCID

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Author profile →

2 papers

Recent·Most cited

A framework for evaluating edited cell libraries created by massively parallel genome engineering

Simon E. Cawley, Eric Abbate, Christopher G. Abraham, Steven Alvarez, Mathew Barber, Scott Bolte, Jocelyne Bruand, Deanna M. Church, Clint Davis, Matthew Estes, Stephen Federowicz, Richard J. Fox, Miles W. Gander, Andrew D. Garst, Gozde Gencer, , Michael S. Graige

The paper introduces a framework for evaluating edited cell libraries generated by genome engineering, defining metrics and connecting analysis to phenotyping approaches.

bioRxiv · Sep 23, 2021 · PreprintGenomics

Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks

Bryan A. Leland, Angela C. Chen, Amy Zhao, Robert C. Wharton, Megan C. King

The paper develops a single-cell microscopy assay to study resection mechanisms of DNA double-strand breaks in S. pombe and finds that 53BP1 and Rev7 repress RecQ helicase-dependent long-range resection.

eLife · Apr 26, 2018Peer-reviewedGenetics