Megan C. King

This study shows that O-GlcNAc modification of nucleoporins modulates nuclear pore complex permeability in response to mechanical and osmotic cues.

This study shows that Kms1 and Cbp1 cooperate to ensure accurate homology-directed DNA repair at the nuclear periphery in S. pombe by preventing recombination and incorrect template use.

This study identifies SUN2 as a mediator of nuclear mechanosensing in fibrosis, showing it drives chromatin remodeling and fibrotic gene expression in response to mechanical stiffness.

This study shows that loss of Sun2 reduces extracellular matrix production and prevents lung fibrosis by disrupting nuclear mechanosensing.

This study identifies JAK1 as a driver of tumor cell radiosensitivity and shows that Kif18a inhibition can counteract therapeutic resistance by exacerbating mitotic stress.

This paper introduces pan-Expansion Microscopy to visualize nuclear pore complex plasticity, revealing LINC complex-dependent diameter biases and nucleoporin repositioning in an ALS model.

This paper shows that tracking multiple identically or alternately labeled chromatin loci can reliably determine their genomic positions over time, enabling the study of chromatin dynamics in live cells.

This study quantifies the timeline of nuclear autophagy in yeast, revealing a role for Dnm1 in nuclear envelope remodeling during cargo removal.

The paper identifies that TMEJ is optimally licensed during mitotic commitment and is regulated by PLK1, with DNA2 deficiency impairing TMEJ by delaying S-phase progression.

This study investigates telomere maintenance in fission yeast lacking telomerase, showing that TERRA RNA and shelterin component changes support recombination-based telomere maintenance.

The paper shows LEM domain proteins Heh1 and Heh2 have opposing roles in adaptation through copy number variation and transcriptional induction of genome instability.

The paper develops a single-cell microscopy assay to study resection mechanisms of DNA double-strand breaks in S. pombe and finds that 53BP1 and Rev7 repress RecQ helicase-dependent long-range resection.