Programmable pathway profiles reveal signaling principles of TGF-β superfamily receptors
Bo Gu, James M. Linton, Brice Graham Hendrickson, Hengyu Li, Ron Hadas, Gal Manella, Jan Gregrowicz, Bryan Anggito, Rong Lu, Michael B. Elowitz
The paper develops Pathway Sculptor to systematically modulate TGF-β receptor subsets, revealing functional interactions between BMP and TGF-β pathways and their collaborative signaling mechanisms.
bioRxiv · Jun 15, 2025 · PreprintSynthetic Biology