James M. Linton

This study designs synthetic reaction-diffusion circuits in mammalian cells to generate spatial patterns with controllable spatial scales.

This paper introduces LagTag, a method to recover both earlier and endpoint chromatin states in mammalian cells, and applies it to study dynamic chromatin transitions during stem cell differentiation.

The paper develops Pathway Sculptor to systematically modulate TGF-β receptor subsets, revealing functional interactions between BMP and TGF-β pathways and their collaborative signaling mechanisms.

This paper engineers protease-based protein circuits that selectively kill RAS-mutant cancer cells and suppress tumors, showing resistance reduction and cytotoxicity independent of oncogene addiction.

The paper describes a synthetic protein circuit that performs winner-take-all neural network computation in mammalian cells using engineered protein interactions.

The paper develops a mathematical model to show how promiscuous ligand-receptor interactions enable efficient cellular addressing through combinatorial signaling.

The paper investigates how BMP ligands interact combinatorially and context-dependently through receptor expression, revealing equivalence groups and a biochemical model for signaling complex formation.