Rong Lu

QuantCell: machine learning based cell annotation integrating qualitative and quantitative imaging profiles

QuantCell improves cell annotation in spatial imaging by integrating quantitative and qualitative data, achieving high accuracy and detecting rare cell types.

Tracking Human HSCs and MPPs in Mice Reveals Distinct Clonal Dynamics and Responses to Pre-transplant Conditioning

GP130 Y814 SIGNALING IS REQUIRED FOR THE DYNAMIN-MEDIATED ENDOCYTOSIS, MAPK/P38 ACTIVATION AND PERSISTENCE OF CHRONIC SYSTEMIC INFLAMMATION INDUCED BY HIGH FAT DIET

This study shows that gp130-Y814 signaling is critical for dynamin-mediated endocytosis, MAPK/p38 activation, and chronic inflammation persistence in high-fat diet models.

Programmable pathway profiles reveal signaling principles of TGF-β superfamily receptors

The paper develops Pathway Sculptor to systematically modulate TGF-β receptor subsets, revealing functional interactions between BMP and TGF-β pathways and their collaborative signaling mechanisms.

Cellular and molecular networks of intercellular signaling in bone marrow hematopoiesis

The paper develops CellSIP to analyze cell-cell signaling in hematopoiesis, identifies feedback mechanisms and pathway correlations, and provides a resource for exploring intercellular signaling.

Aberrant Clonal Hematopoiesis Following Lentiviral Transduction of HSPC in a Rhesus Macaque

This paper reports a case of clonal hematopoiesis in a rhesus macaque following lentiviral transduction of HSPC with a strong retroviral promoter, leading to gene overexpression and aberrant splicing.

Clonal Level Lineage Commitment Pathways of Hematopoietic Stem Cells In Vivo

This study maps clonal lineage commitment pathways of hematopoietic stem cells in vivo, revealing differences in clonal behavior under homeostasis and after hematopoietic depletion.

Functional Compensation Between Hematopoietic Stem Cells In Vivo

The paper shows hematopoietic stem cells in mice compensate for functional deficiencies by increasing clonal expansion during lymphopoiesis, maintaining blood supply and influencing blood cell types.