Author

Kalvis Brangulis

Latvian Biomedical Research and Study CentreORCID 0000-0003-0757-7462Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Alan WangiD· 1 shared Alejandro LIanes· 1 shared Ashley L. MarcinkiewicziD· 1 shared Bryanna Nicole FayneiD· 1 shared Ching-Lin Hsieh· 1 shared Dagnija TupiņaiD· 1 shared Ināra Akopjana· 1 shared Jill Malfetano· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Alan WangORCID

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2 papers

Recent·Most cited

ImmunologyNature CommunicationsPeer-reviewedApr 6, 2025

Mechanistic insights into structure-based design of a Lyme disease subunit vaccine

Kalvis Brangulis, Jill Malfetano, Ashley L. Marcinkiewicz…·Yi‐Pin Lin

This study demonstrates that structure-based mutagenesis of CspZ-YA improves antigen stability and immunogenicity, supporting its use in Lyme disease vaccine design.

6 citationstop 5%

mouseprotein structure

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MicrobiologyPLoS neglected tropical diseasesPeer-reviewedSep 23, 2024

Enhancement of clinical signs in C3H/HeJ mice vaccinated with a highly immunogenic Leptospira methyl-accepting chemotaxis protein following challenge

Liana Nunes Barbosa, Alejandro LIanes, Swetha Madesh…·Sreekumari Rajeev

This study evaluates a recombinant Leptospira methyl-accepting chemotaxis protein (MCP) vaccine in C3H/HeJ mice, finding it elicits an immune response but does not prevent disease and may exacerbate clinical signs.

1 citation

mouseproteomics

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