Repeated Mild Head Injury Establishes a Senescent Cranial Bone Marrow Niche that Impairs Brain Metabolism
Patrick J. Devlin, Romeesa Khan, Trang H. Do, Bryce E. West, Janelle M. Korf, Gary U. Guzman, Chunfeng Tan, John Ahn, Rene Flores, Micheal E. Maniskas, Sean P. Marrelli, Anna Malovannaya, Erica L. Underwood, Rodney M. Ritzel
This study shows that repeated mild head injury leads to senescence in cranial bone marrow, impairing brain metabolism and causing systemic inflammation.
bioRxiv · Jan 13, 2026 · PreprintNeuroscience