Gary Guzman

This study examines chronic neurological changes after ischemic stroke in mice and humans, finding persistent inflammation, neuronal damage, and signs of accelerated aging in the brain.

In vivo lineage tracing and targeted ablation in autochthonous mouse lung adenocarcinoma establish the Slc4a11+ high-plasticity cell state as a bidirectional transition hub driving tumor progression and therapy resistance.

This study shows that repeated mild head injury leads to senescence in cranial bone marrow, impairing brain metabolism and causing systemic inflammation.

scVital integrates scRNA-seq data across species to identify conserved cell states and reduce batch effects using a variational autoencoder and discriminator.