Rodney M. Ritzel

Molecular MRI of Neuroinflammation in Alzheimer's Disease using a Folate-targeted Nanoprobe

This study uses a folate-targeted nanoprobe to image neuroinflammation in Alzheimer's disease models via molecular MRI, showing enhanced signal in transgenic mice with pro-inflammatory microglia.

Neuropathological hallmarks during the chronic phase of ischemic stroke in mice and humans

This study examines chronic neurological changes after ischemic stroke in mice and humans, finding persistent inflammation, neuronal damage, and signs of accelerated aging in the brain.

Repeated Mild Head Injury Establishes a Senescent Cranial Bone Marrow Niche that Impairs Brain Metabolism

This study shows that repeated mild head injury leads to senescence in cranial bone marrow, impairing brain metabolism and causing systemic inflammation.

Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction.

This study examines how high-fat diet and brain trauma interact to alter macrophages in adipose tissue and microglia in the brain, leading to worsened cognitive function.

Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with hyperphagocytosis and inflammatory neurodegeneration

This study shows that brain injury accelerates age-related microglial changes linked to hyperphagocytosis and neurodegeneration in old mice.

Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits

This study shows that removing microglia with a CSF1R inhibitor after TBI reduces neurodegeneration and improves neurological outcomes.