Renalase inhibition regulates β cell metabolism to defend against acute and chronic stress
Tara L. MacDonald, Birgitta A. Ryback, Jéssica Aparecida da Silva Pereira, Siying Wei, Bryhan Mendez, Erica P. Cai, Yuki Ishikawa, Meagan Arbeau, Gordon C. Weir, Susan Bonner‐Weir, Stephan Kissler, Yi Peng
This study shows that inhibiting Renalase protects β cells from stress by shifting metabolism towards glycolysis and GSH synthesis in both mice and humans.
Molecular Metabolism · Feb 21, 2025Peer-reviewedPhysiology