Yuki Ishikawa

The human RNA-DNA interactome is cell type-specific and dynamic

The paper maps RNA-DNA interactions in 16 human cell types, showing cell-type-specific and dynamic networks that correlate with gene regulation and disease traits.

Imputation Disparities Driven by Recent Selectionand Their Impact on Disease Risk Estimation in East and Southeast Asian Populations

The paper evaluates imputation performance in East and Southeast Asian populations, showing that recent selection affects variant detection and polygenic risk score estimation.

Associations between mosaic loss and schizophrenia or bipolar disorder of young onset

The paper investigates the association between mosaic loss events in blood and schizophrenia or bipolar disorder, finding increased odds ratios in young-onset cases.

Renalase inhibition regulates β cell metabolism to defend against acute and chronic stress

This study shows that inhibiting Renalase protects β cells from stress by shifting metabolism towards glycolysis and GSH synthesis in both mice and humans.

Sequence sensitivity of open chromatin reveals constrained regulatory elements underlying human traits

The paper introduces CAMBUS, a machine-learning framework to identify functionally important open chromatin regions by measuring sequence sensitivity, and finds these regions are enriched for evolutionary constraint and disease-related variants.