Author

Céline Mouton

Ludwig Cancer Research

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Molecular Biology· 1

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Approach:experimental assay· 1 Organism:human· 1

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Christian Pecquet· 1 shared Emilie LeroyiD· 1 shared Gabriel LevyiD· 1 shared Ian C. Brett· 1 shared Jean‐Philippe DefouriD· 1 shared Judith StaerkiD· 1 shared Lidvine Genet· 1 shared Nicolas PapadopoulosiD· 1 shared

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2023-2023 · peak 1/yr

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1 shared paperMolecular Biology

Christian Pecquet

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1 paper

Recent·Most cited

Molecular BiologyeLifePeer-reviewedJun 20, 2023

Constitutive Activation and Oncogenicity Are Mediated by Loss of Helical Structure at the Cytosolic Boundary of the Thrombopoietin Receptor

Jean‐Philippe Defour, Emilie Leroy, Sharmila Dass…·Stefan N. Constantinescu

The paper investigates how mutations in the thrombopoietin receptor (TpoR) affect its activation and oncogenicity by altering the helical structure at the cytosolic boundary of the transmembrane domain.

10 citations

humanexperimental assay

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