Colibactin-producing E. coli promote carcinogenesis of gastroesophageal adenocarcinoma and simultaneously induce autophagy and differentiation
Andrea Proaño-Vasco, David Obwegs, Kerstin Bruder, Céline Ritzkowski, Sophia Eichner, Lauren Houle, Yiwei Sun, Ceylan Tanes, Lioba Klaas, Linus R. Schömig, Donja Sina Mohammad-Shahi, Kyle L. Bittinger, Kenneth K. Wang, Anil K. Rustgi, Gary W. Falk, , Michael Quante
This study shows colibactin-producing E. coli promote GEAC carcinogenesis by increasing proliferation, DNA damage, and cancer pathways, while also inducing autophagy and differentiation.
bioRxiv · Nov 10, 2025 · PreprintCancer Biology