Postnatal Maturation of Dendritic Epidermal T Cells and Langerhans Cells Follows Distinct Differentiation Trajectories Independent of Microbiota
David Obwegs, Alexander Oschwald, Lara M. Koetter, Cylia Crisand, Sidney Doerr, Kerstin Bruder, Solveig Runge, Nisreen Ghanem, Vidmante Fuchs, Marleen Eckert, Julia Kolter, Daniel Erny, Marco Prinz, Susana Minguet, Wolfgang W A Schamel, , S Sagar
This study maps the postnatal differentiation trajectories of dendritic epidermal T cells and Langerhans cells in mice, showing they develop independently of each other and microbial colonization.
bioRxiv · Apr 7, 2026 · PreprintImmunology