Author

R. J. Ferreira

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. M. M. Villamil Giraldo· 1 shared C. A. Bonito· 1 shared D. J. V. A. dos Santos· 1 shared J.-P. Gillet· 1 shared M. N. D. S. Cordeiro· 1 shared M.-J. U. Ferreira· 1 shared P. Kasson· 1 shared P. M. Kasson· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 13 mutual co-author links

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1 shared paperMicrobiology

A. M. M. Villamil Giraldo

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiophysicsbioRxivJun 30, 2022

Long-range communication between transmembrane- and nucleotide-binding domains does not depend on drug binding to mutant P-glycoprotein

C. A. Bonito, R. J. Ferreira, M.-J. U. Ferreira…·D. J. V. A. dos Santos

This study evaluates how four P-gp mutations affect drug-binding and efflux mechanisms, finding that changes in drug efflux are more related to drug specificity than signal transmission.

DOI 10.1080/07391102.2023.2181633

humanexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivPreprintOct 8, 2020

Simulation-guided engineering of antibiotics for improved bacterial uptake

R. J. Ferreira, V. Aguilar, A. M. M. Villamil Giraldo, P. M. Kasson

This study develops physics-based methods to predict and optimize antibiotic uptake in Gram-negative bacteria, showing strong correlation with experimental data and antimicrobial activity.

DOI 10.1101/2020.10.08.330332

E. colideep learning

𝕏 PostBluesky

BiochemistrybioRxivJun 11, 2019

Antibiotic uptake across gram-negative outer membranes: better predictions towards better antibiotics

R. J. Ferreira, P. Kasson

The paper develops a computational method and experimental assay to predict antibiotic uptake across gram-negative outer membranes, showing strong correlation between simulations and experimental permeability.

DOI 10.1021/acsinfecdis.9b00201

deep learningstatistical model

𝕏 PostBluesky