Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric state
K. Rahman, C. A. Coomer, S. Majdoul, S. Ding, S. Padilla-Parra, A. A. Compton
This study identifies a conserved GxxxG motif in IFITM3 that drives oligomerization and antiviral activity by promoting membrane rigidity.
bioRxiv · May 14, 2020Evolutionary Biology