S. Padilla-Parra

Early steps of multi-receptor viral interactions dissected by high-density, multi-color single molecule mapping in living cells

The paper develops a high-density, multi-color single-molecule mapping method to study viral-receptor interactions in living cells and finds coordinated receptor diffusion affects viral residence time and infectivity.

Live Cell Multicolour Lifetime Imaging Using Genetically Encodable Fluorophores

The paper demonstrates simultaneous imaging of nine fluorescent proteins using FLIM and PIE, and introduces a method to unmix spectrally similar FPs pixel-by-pixel.

Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress

The paper shows that glycolysis downregulation is a hallmark of HIV-1 latency and that targeting antioxidant pathways can reactivate latent HIV-1.

Structure and Dynamics of HIV-1 Env Trimers on Native Virions Engaged in Living T Cells

This study investigates the conformational dynamics of HIV-1 Env trimers on virions interacting with live T cells, revealing how Env clustering and intramolecular dynamics influence immune evasion.

Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric state

This study identifies a conserved GxxxG motif in IFITM3 that drives oligomerization and antiviral activity by promoting membrane rigidity.

Single-cell glycolytic activity regulates membrane tension 1 and HIV-1 fusion

This study links host cell glycolytic activity to membrane tension and shows how it affects HIV-1 fusion in single cells.

Robin Hood: non-fitting, non-smoothing image detrending for bleaching correction

The paper introduces Robin Hood, an automatic detrending algorithm for fluorescence microscopy that performs well at low intensities, and evaluates it using simulated and low photon budget live cell images.

Chromatin Condensation Fluctuations Rather Than Steady-State Predict Chromatin Accessibility

The paper shows chromatin condensation fluctuations, not steady-state condensation, predict accessibility of acetylated histone H4 to bromodomains in live cells.