Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis
R. Cavalieri, M. K. Hazebroek, C. A. Cotrim, Y. Lee, E. R. S. Kunji, M. Jastroch, S. Keipert, P. G. Crichton
The paper identifies activators of UCP1 using membrane protein thermostability shift analysis, finding ibuprofen as a novel activator with potential therapeutic implications.
bioRxiv · Feb 3, 2022Biochemistry