Author

S. Keipert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

M. Jastroch· 3 shared A. Bartelt· 1 shared A. Boettcher· 1 shared A. Feuchtinger· 1 shared A. Francisco· 1 shared A. Israel· 1 shared A. M. Cypess· 1 shared A. S. Jung· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCell Biology

M. Jastroch

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

IF1 is a cold-regulated switch of ATP synthase to support thermogenesis in brown fat

H. S. Brunetta, A. S. Jung, F. B. Valdivieso-Rivera, S. C. C. Zani, V. Furino, A. Francisco, P. M. M. Moraes-Vieira, S. Keipert, M. Jastroch, L. O. Martinez, C. H. Sponton, R. F. Castilho, M. A. Mori, A. Bartelt

This paper identifies IF1 as a cold-regulated inhibitor of ATP synthase that facilitates reverse mode activity in brown fat to support thermogenesis.

bioRxiv · Jul 27, 2023 · PreprintCell Biology

Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis

R. Cavalieri, M. K. Hazebroek, C. A. Cotrim, Y. Lee, E. R. S. Kunji, M. Jastroch, S. Keipert, P. G. Crichton

The paper identifies activators of UCP1 using membrane protein thermostability shift analysis, finding ibuprofen as a novel activator with potential therapeutic implications.

bioRxiv · Feb 3, 2022Biochemistry

Identification and characterization of distinct murine brown adipocyte lineages

S. Ussar, R. Karlina, D. Lutter, V. Miok, D. S. Fischer, I. Altun, T. Schoettl, K. Schorpp, A. Israel, C. Cero, J. W. Johnson, I. Kapser-Fischer, A. Boettcher, S. Keipert, A. Feuchtinger, , A. M. Cypess

The paper identifies and characterizes distinct murine brown adipocyte lineages using single-cell RNA sequencing and functional analysis.

bioRxiv · Aug 24, 2020 · PreprintCell Biology

Mitochondria Are Physiologically Maintained At Close To 50 °C

D. Chretien, P. Benit, H.-H. Ha, S. Keipert, R. El-Khoury, Y.-T. Chang, M. Jastroch, H. Jacobs, P. Rustin, M. Rak

The paper measures mitochondrial temperature in situ and finds it can exceed 50°C under physiological conditions, influenced by respiratory chain activity and thermogenic enzymes.

bioRxiv · Aug 21, 2017Cell Biology