M. Jastroch

IF1 is a cold-regulated switch of ATP synthase to support thermogenesis in brown fat

This paper identifies IF1 as a cold-regulated inhibitor of ATP synthase that facilitates reverse mode activity in brown fat to support thermogenesis.

Cold-induced expression of a truncated Adenylyl Cyclase 3 acts as rheostat to brown fat function.

The paper identifies a cold-inducible truncated Adcy3 mRNA isoform, Adcy3-at, which acts as a rheostat to regulate brown fat function by limiting cAMP activity during obesity.

Acinar-to-ductal metaplasia in the pancreas requires a glycolytic switch and functional mitochondria

This study identifies a glycolytic switch and functional mitochondria as essential for acinar-to-ductal metaplasia, a key step in pancreatic carcinogenesis.

Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis

The paper identifies activators of UCP1 using membrane protein thermostability shift analysis, finding ibuprofen as a novel activator with potential therapeutic implications.

Mitochondria Are Physiologically Maintained At Close To 50 °C

The paper measures mitochondrial temperature in situ and finds it can exceed 50°C under physiological conditions, influenced by respiratory chain activity and thermogenic enzymes.

Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades

The paper shows that inactivation of UCP1 occurred in multiple placental mammal clades and is linked to reduced metabolic intensity and increased body mass during periods of global cooling.