Author

C. A. Heckman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Malyutina· 1 shared A. Pessia· 1 shared E. Gholizadeh· 1 shared F. Ianevski· 1 shared J. J. Miettinen· 1 shared J. Saarela· 1 shared J. TangiD· 1 shared M. Jafari· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Malyutina

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3 papers

Recent·Most cited

Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling

M. Mirzaie, E. Gholizadeh, J. J. Miettinen, T. Ruokoranta, F. Ianevski, J. Saarela, M. Manninen, S. Miettinen, C. A. Heckman, M. Jafari

This paper identifies effective and low-toxicity drug combinations for AML using a bipartite network model and patient-derived data, finding ruxolitinib-ulixertinib and sapanisertib-LY3009120 as the most synergistic.

bioRxiv · May 25, 2023Cancer Biology

How Filopodia Respond to Calcium in the Absence of a Calcium-binding Structural Protein: They Use Rapid Transit

C. A. Heckman, O. M. Ademuyiwa, M. L. Cayer

The paper investigates how filopodia respond to calcium changes in the absence of calcium-binding proteins, finding that vesicle recycling and TRPC1 exocytosis regulate filopodia extension.

Cell Communication and Signaling · Aug 26, 2022Peer-reviewedCell Biology

Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer

A. Malyutina, M. M. Majumder, W. Wang, A. Pessia, C. A. Heckman, J. Tang

This paper introduces a drug combination sensitivity score (CSS) to efficiently evaluate drug synergy in cancer, showing high reproducibility and predictive accuracy.

bioRxiv · Jan 4, 2019Pharmacology & Toxicology