Author

C. A. Ng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:electrophysiology· 2 Research Focus:variant effect prediction· 2 Research Focus:cell signaling & trafficking· 1 Assay:proteomics· 1

Frequent Co-Authors

A. P. Hill· 2 shared J. Farr· 2 shared J. I. Vandenberg· 2 shared B. M. Kroncke· 1 shared C. D. Cox· 1 shared D. Cheng· 1 shared D. Fatkin· 1 shared D. W. Mitchell· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

A. P. Hill

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3 papers

Recent·Most cited

A Massively Parallel Trafficking Assay Accurately Predicts Loss of Channel Function in KCNH2 Variants

C. A. Ng, R. Ullah, J. Farr, A. P. Hill, K. A. Kozek, L. R. Vanags, D. W. Mitchell, B. M. Kroncke, J. I. Vandenberg

The paper develops a trafficking assay to predict KCNH2 variant function, showing high accuracy in classifying loss-of-function variants compared to existing methods.

bioRxiv · Jul 10, 2021Biophysics

Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology

C. A. Ng, J. Farr, P. Young, M. J. Windley, M. D. Perry, A. P. Hill, J. I. Vandenberg

This paper describes a high-throughput method to phenotype KCNH2 variants using automated patch-clamp electrophysiology and Flp-In HEK293 cells, enabling rapid assessment of variant function.

bioRxiv · Feb 2, 2021Biophysics

Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations

J. V. Li, C. A. Ng, D. Cheng, M. Yao, Y. Guo, Z.-Y. Yu, Y. Ramaswamy, L. A. Ju, P. W. Kuchel, M. P. Feneley, D. Fatkin, C. D. Cox

The paper shows that N-linked glycosylation in Piezo1 channels is essential for plasma membrane trafficking and that mutations affecting this process are linked to disease.

bioRxiv · Nov 30, 2020Biophysics