Author

C. A. Tower

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

J. D. Mougous· 2 shared S. B. Peterson· 2 shared Y. Wang· 2 shared A. Krishnakumar· 1 shared B. A. Jackson· 1 shared D. Baker· 1 shared D. T. Hung· 1 shared E. Liu· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

J. D. Mougous

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Author profile →

2 papers

Recent·Most cited

Essential and virulence-related protein interactions of pathogens revealed through deep learning

I. R. Humphreys, J. Zhang, M. Baek, Y. Wang, A. Krishnakumar, J. Pei, I. Anishchenko, C. A. Tower, B. A. Jackson, T. Warrier, D. T. Hung, S. B. Peterson, J. D. Mougous, Q. Cong, D. Baker

This study uses deep learning to predict protein-protein interactions in bacterial pathogens, identifying new complexes involving essential genes and virulence factors, with half of tested predictions validated.

bioRxiv · Apr 12, 2024 · PreprintBiochemistry

Discovery of a unique pathway for glutathione utilization in Francisella

Y. Wang, H. E. Ledvina, C. A. Tower, S. Kambarev, E. Liu, J. C. Charity, L. S. M. Kreuk, Q. Chen, L. A. Gallagher, M. C. Radey, G. F. Rerolle, Y. Li, K. M. Penewit, S. Turkarslan, S. J. Skerrett, , J. D. Mougous

This study identifies a unique GSH utilization pathway in Francisella, revealing a pseudogenized transporter gene in pathogenic strains and its role in environmental niches.

bioRxiv · Feb 2, 2023Microbiology