Author

H. E. Ledvina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 5 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Assay:metabolomics· 1

Frequent Co-Authors

J. D. Mougous· 3 shared M. C. Radey· 3 shared S. B. Peterson· 3 shared A. T. Whiteley· 2 shared H. Zhou· 2 shared K. D. Corbett· 2 shared K. M. Penewit· 2 shared L. A. Gallagher· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

J. D. Mougous

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Bacterial antiviral defense pathways encode eukaryotic-like ubiquitination systems

L. R. Chambers, Q. Ye, J. Cai, M. Gong, H. E. Ledvina, H. Zhou, A. T. Whiteley, R. T. Suhandynata, K. D. Corbett

This study shows bacteria have a complete ubiquitination pathway similar to eukaryotes, with structural and functional parallels to eukaryotic systems.

bioRxiv · Sep 26, 2023 · PreprintBiophysics

Discovery of a unique pathway for glutathione utilization in Francisella

Y. Wang, H. E. Ledvina, C. A. Tower, S. Kambarev, E. Liu, J. C. Charity, L. S. M. Kreuk, Q. Chen, L. A. Gallagher, M. C. Radey, G. F. Rerolle, Y. Li, K. M. Penewit, S. Turkarslan, S. J. Skerrett, , J. D. Mougous

This study identifies a unique GSH utilization pathway in Francisella, revealing a pseudogenized transporter gene in pathogenic strains and its role in environmental niches.

bioRxiv · Feb 2, 2023Microbiology

cGASylation by a bacterial E1-E2 fusion protein primes antiviral immune signaling

H. E. Ledvina, Q. Ye, Y. Gu, Y. Quan, R. K. Lau, H. Zhou, K. D. Corbett, A. T. Whiteley

The paper shows that a bacterial E1-E2 fusion protein, Cap2, primes cGAS for antiviral signaling through a process called cGASylation, which increases cGAMP production by ~50-fold.

bioRxiv · Mar 31, 2022Microbiology

Coordinately regulated interbacterial antagonism defense pathways constitute a bacterial innate immune system

S.-Y. Ting, K. D. LaCourse, H. E. Ledvina, R. Zhang, M. C. Radey, H. D. Kulasekara, R. Somavanshi, S. K. Bertolli, L. A. Gallagher, J. Kim, K. M. Penewit, S. J. Salipante, L. Xu, S. B. Peterson, J. D. Mougous

This study identifies three conserved interbacterial antagonism resistance clusters in Pseudomonas aeruginosa that function independently and provide specific defense against phospholipase toxins.

bioRxiv · Aug 22, 2021Microbiology

An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations

M. H. de Moraes, F. Hsu, D. Huang, D. E. Bosch, J. Zeng, M. C. Radey, N. Simon, H. E. Ledvina, J. P. Frick, P. A. Wiggins, S. B. Peterson, J. D. Mougous

This study shows that interbacterial toxins like DddA can induce mutations in surviving bacterial populations, promoting adaptation through direct DNA mutagenesis.

bioRxiv · Sep 23, 2020Microbiology