Myeloid Cell Glucocorticoid, Not Mineralocorticoid Receptor Signaling, Contributes to Salt-Sensitive Hypertension in Humans via Cortisol
C. Albritton, M. Demirci, K. Neikirk, J. Ishimwe, A. Mutchler, Q. Sheng, C. L. Laffer, C. N. Wanjalla, T. Ahmad, A. P. Haynes, M. Saleem, H. K. Beasley, A. G. Marshall, Z. Vue, A. T. Ikizler, , A. Kirabo
This study identifies glucocorticoid receptor (GR) signaling in myeloid cells as a key contributor to salt-sensitive hypertension (SSBP) through SGK1 and IsoLG pathways, distinct from mineralocorticoid receptor (MR) mechanisms.
bioRxiv · Jun 10, 2024 · PreprintPhysiology